Serum bisphenol-A concentration and sex hormone levels in men

ObjectiveTo evaluate the association between serum bisphenol-A (BPA) concentration and sex hormone levels in men.DesignCross-sectional study.SettingNot applicable.Patient(s)A total of 290 men with or without BPA exposure in the workplace.Intervention(s)None.Main Outcome Measure(s)Serum sex hormone levels.Result(s)After adjustment for potential confounders using linear regression, increasing serum BPA concentration was statistically significantly associated with [1] decreased androstenedione levels, [2] decreased free testosterone levels, [3] decreased free androgen index, and [4] increased sex hormone-binding globulin levels. Comparison of hormone levels between workers exposed and unexposed to BPA showed similar associations.Conclusion(s)Exposure to a high BPA level may impact sex hormone levels in men.