کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3932594 1253332 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of paternal age on assisted reproduction outcome
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
The effect of paternal age on assisted reproduction outcome
چکیده انگلیسی

ObjectiveTo summarize the current knowledge about the association between paternal age and assisted reproductive technology (ART) outcomes. In contrast to the extensive investigation of the relationship between maternal age and the success of ART, there are few studies examining the effect of paternal age on ART outcomes.DesignSystematic review of the literature. By means of a PubMed literature search using the phrases “paternal age”, “male age”, and “assisted reproductive technology”, we identified articles that investigated the role of male age in in vitro reproduction techniques.Result(s)The 10 studies included in this review did not show a clear correlation between advanced paternal age and rates of fertilization, implantation, pregnancy, miscarriage, and live birth. Paternal age was not found to affect embryo quality at the cleavage stage (days 2–3). However, a significant decrease in blastocyst embryo formation was associated with increased paternal age, probably reflecting male genomic activation within the embryo. Except for volume, characteristics of semen such as motility, concentration, and morphology did not decrease with age.Conclusion(s)There is insufficient evidence to demonstrate an unfavorable effect of paternal age on ART outcomes. Further study with well-defined entry criteria and uniform reporting of outcomes is needed to investigate the subject.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 95, Issue 1, January 2011, Pages 1–8
نویسندگان
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