کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3933541 1253353 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association study of vascular endothelial growth factor polymorphisms with the risk of recurrent spontaneous abortion
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Association study of vascular endothelial growth factor polymorphisms with the risk of recurrent spontaneous abortion
چکیده انگلیسی

ObjectiveTo investigate the association of vascular endothelial growth factor (VEGF) polymorphisms (-2578C>A, -1154G>A, -634G>C, 936C>T) with idiopathic recurrent spontaneous abortion (RSA) in Koreans.DesignProspective case-control study.SettingUniversity-based hospital.Patient(s)Two hundred and fifteen patients with a history of two or more unexplained consecutive pregnancy losses and 113 healthy controls with at least one live birth and no history of pregnancy loss.Intervention(s)None.Main Outcome Measure(s)Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses were performed for the -2578C>A and 936C>T genotypes. Real-time PCR was also used to analyze the -1154G>A and -634G>C genotypes.Result(s)The GA (adjusted odds ratio [AOR] 2.774; 95% confidence interval [CI] 1.512–5.092) genotype of the VEGF -1154G>A polymorphism was significantly different between women with idiopathic RSA and controls. The difference in overall (GA + AA) frequency was also marginally significant between the controls and patients with idiopathic RSA (AOR, 2.006; 95% CI, 1.158–3.473). The differences in frequencies of the A-A-G-T and C-A-G-T haplotypes of the VEGF polymorphisms (-2578C>A, -1154G>A, -634G>C, 936C>T) were marginally significant between the patient and control groups.Conclusion(s)This study suggests that VEGF polymorphisms and haplotypes are a genetic determinant for the risk of idiopathic RSA in Korean women.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 93, Issue 4, 1 March 2010, Pages 1244–1247
نویسندگان
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