کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3933651 1253358 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Placental pathology in egg donor pregnancies
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Placental pathology in egg donor pregnancies
چکیده انگلیسی

ObjectiveTo determine placental pathology and immune response at the maternal-fetal interface in pregnancies conceived by IVF via egg donation compared with nondonor IVF pregnancies.DesignRetrospective case-control study.SettingAcademic medical center.Patient(s)The study population included 20 egg donor and 33 nondonor IVF pregnancies of >24 weeks' gestation.Intervention(s)None.Main Outcome Measure(s)Perinatal complications (gestational hypertension, abruption, preterm delivery, cesarean section), microscopic features indicating an immune response and trophoblast damage, and characterization of inflammatory cells using immunohistochemistry.Result(s)There was an increase in gestational hypertension and preterm delivery in egg donor pregnancies. Dense fibrinoid deposition in the basal plate with severe chronic deciduitis containing significantly increased numbers of T helper and natural killer cells were demonstrated in egg donor placentas. Trophoblast damage was also increased in the preterm egg donor group.Conclusion(s)There are significant histological and immunohistochemical differences between the placentas of egg donor and nondonor IVF pregnancies. The increased immune activity and fibrinoid deposition at the maternal-fetal interface of egg donor pregnancies could represent a host versus graft rejection-like phenomenon.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 93, Issue 2, 15 January 2010, Pages 397–404
نویسندگان
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