Live birth after allografting of ovarian cortex between monozygotic twins with Turner syndrome (45,XO/46,XX mosaicism) and discordant ovarian function

ObjectiveTo report the restoration of ovarian function in a woman with Turner syndrome by allografting ovarian cortex from her monozygotic twin.DesignCase report.SettingGynecology research unit in a university hospital.Patient(s)A 37-year-old woman with Turner syndrome who had suffered premature ovarian failure (POF) at the age of 15.Intervention(s)In this woman, we performed ovarian cortex transplantation. The donor was her monozygotic twin who had not experienced POF and who had had two normal deliveries.Main Outcome Measure(s)Restoration of ovarian activity and pregnancy.Result(s)Restoration of ovarian function was achieved 3 months after transplantation. After 7 months of regular cycles, spontaneous pregnancy occurred. The patient delivered a healthy baby girl weighing 2,850 g at 38 weeks of gestation.Conclusion(s)Girls with Turner syndrome suffer accelerated loss of ovarian follicles and only 2%–5% experience spontaneous menses with the potential to achieve pregnancy without medical intervention. This manuscript reports the first live birth after allografting between monozygotic twins with 45,XO/46,XX mosaicism and discordant growth pattern and ovarian function.