کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3935799 1253426 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Use of suboptimal sperm increases the risk of aneuploidy of the sex chromosomes in preimplantation blastocyst embryos
ترجمه فارسی عنوان
استفاده از اسپرم های غیرپرومتالی خطر ابتلا به کروموزوم های جنسی را در جنین های قبل از بلافاصله بلوط افزایش می دهد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

ObjectiveTo compare autosomal and sex chromosome aneuploidy rates of embryos derived from sperm with abnormal and normal parameters.DesignRetrospective cohort study.SettingAssisted reproduction center.Patient(s)Three thousand eight hundred thirty-five embryos generated from 629 couples undergoing IVF.Intervention(s)None.Main Outcome Measure(s)Incidence of aneuploidy in the trophectoderm of blastocyst embryos derived from standard IVF embryos and intracytoplasmic (ICSI) males with normal and oligozoospermic semen samples, in couples with donor eggs (mean maternal age, 25.0 years) and their own eggs (mean maternal age, 35.4 years).Result(s)The rate of sex chromosome aneuploidy was significantly (around threefold) higher in the oligozoospermic group compared with in both control groups (standard vs. ICSI insemination). This applied whether donor (young) or own (older) eggs were used. Significant differences were seen in the oligozoospermic samples for autosomes 1, 2, 11 (own eggs), and 18 (donor eggs) compared with both control groups; however, no significant difference was seen between each of the treatment groups for the overall rate of autosomal aneuploidy. No significant differences were seen between the two control groups (normozoospermic males, standard vs. ICSI insemination) in either of the egg group types for any chromosome pairs.Conclusion(s)Severe male factor infertility is associated with a significant increase in the occurrence of sex chromosome abnormalities in blastocyst embryos compared with in embryos derived from normal semen samples. Aneuploidy rates in embryos derived from sperm with normal parameters were not significantly different whether ICSI or standard insemination was used to achieve fertilization. These results highlight severe male factor infertility as a possible referral category for preimplantation comprehensive chromosomal screening.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 104, Issue 4, October 2015, Pages 866–872
نویسندگان
, , , , , , , , , ,