کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3935811 | 1253426 | 2015 | 6 صفحه PDF | دانلود رایگان |
ObjectiveTo estimate the relative contribution of genetic influences and prevalence on endometriosis.DesignAnalysis of self-reported data from a nationwide population-based twin registry.SettingNot applicable.Patient(s)A total of 28,370 women, female monozygotic (MZ) or dizygotic (DZ) twins, who participated in either of two surveys (1998–2002 or 2005–2006).Intervention(s)None.Main Outcome Measure(s)Self-reported endometriosis, validated by medical records.Result(s)A history of endometriosis was reported by 1,228 female twins. The probandwise concordance was 0.21 for MZ and 0.10 for DZ twins. Higher within-pair (tetrachoric) correlation was observed among MZ (0.47) compared with DZ (0.20) twins. The best-fitting model revealed a contribution of 47% by additive genetic factors and the remaining 53% attributed to unique environmental effects.Conclusion(s)Our findings suggest both genetic and unique (nonshared) environmental influences on the complex etiology of endometriosis and support the hypothesis that genes have a strong influence on phenotypic manifestations of endometriosis.
Journal: Fertility and Sterility - Volume 104, Issue 4, October 2015, Pages 947–952