کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3935880 1253427 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prospective, randomized comparison between raloxifene and clomiphene citrate for ovulation induction in polycystic ovary syndrome
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Prospective, randomized comparison between raloxifene and clomiphene citrate for ovulation induction in polycystic ovary syndrome
چکیده انگلیسی

ObjectiveTo compare the ovulation rate between raloxifene and clomiphene citrate (CC) in patients with polycystic ovary syndrome (PCOS).DesignDouble-blind, randomized, superiority clinical trial.SettingTertiary university hospital.Patient(s)Women with ovulatory dysfunction and PCOS based on the Rotterdam criteria.Intervention(s)One of two oral treatments: 5 days of 100 mg/day of CC or R.Main Outcome Measure(s)Ovulation, based on follicle collapse on serial ultrasound and midsecretory serum progesterone concentration (≥3 ng/dL).Result(s)The women with PCOS (n = 82) were randomized to receive CC (n = 40) or raloxifene (n = 42). From these, 68 patients finished the trial according to the protocol (CC: n = 37; raloxifene: n = 31). There were no statistically significant differences between the groups in ovulation rates per an intention-to-treat analysis based on ultrasound alone (CC: 21 of 40 vs. raloxifene: 17 of 42) or on progesterone levels (CC: 16 of 40 vs. raloxifene: 11 of 42). No serious adverse events were observed in either group.Conclusion(s)No statistically significant difference in ovulation was observed between raloxifene and clomiphene citrate in patients with PCOS with ovulatory dysfunction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 96, Issue 3, September 2011, Pages 769–773
نویسندگان
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