کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3936841 | 1253463 | 2009 | 7 صفحه PDF | دانلود رایگان |

ObjectiveTo determine whether polymorphisms of the estrogen receptor α (ERα) and interleukin-10 (IL-10) genes are associated with endometriosis in a Chinese population.DesignAssociation study.SettingUniversity hospital.Patient(s)Chinese women diagnosed with endometriosis by laparotomy or laparoscopy.Intervention(s)Determination of polymorphisms of the ERα and IL-10 genes was performed by polymerase chain reaction and restriction fragment length polymorphism analysis in 214 affected women and 160 controls.Main Outcome Measure(s)Frequency and distribution of PvuII and XbaI polymorphisms of ERα and of BslI, SspI, and RsaI polymorphisms of IL-10.Result(s)There was no significant difference between the endometriosis patients and the control groups in the genotype frequency of ERα-PvuII and promoter of IL-10 gene polymorphisms in the position of -1082. However, the frequency of ERα-XbaI and -592 or -819C alleles of IL-10 in the endometriosis group was significantly higher than that of controls, and further analysis showed that the X allele of ERα-XbaI was associated with endometriosis.Conclusion(s)The X allele of ERα-XbaI and the -592 or -819 C allele of IL-10 are associated with endometriosis.
Journal: Fertility and Sterility - Volume 92, Issue 1, July 2009, Pages 54–60