کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3938874 1253544 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Soluble Fas and gonadal hormones in infertile men with varicocele
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Soluble Fas and gonadal hormones in infertile men with varicocele
چکیده انگلیسی

ObjectiveTo assess gonadal hormones in serum and semen as well as seminal antiapoptotic factor; soluble fibroblast associated (sFas) in infertile men associated with scrotal varicocele.DesignProspective.SettingAcademic setting.PatientsEighty-eight males: fertile healthy controls (Gr1, n = 12), fertile normozoospermia with varicocele (Gr2, n = 31), and infertile oligoasthenozoospermia with varicocele (Gr3, n = 45).Main Outcome Measure(s)Serum and seminal gonadal hormones: follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), and testosterone (T), in addition to seminal sFas.ResultsThere were significant higher mean levels of serum FSH, serum, and seminal LH with significant lower seminal T levels in cases of Gr3 compared with Gr2. Mean seminal sFas in Gr3 were significantly higher than its levels in Gr1 and 2 (mean ± SE 8.34 ± 0.36 vs. 6.8 ± 0.53 and 6.06 ± 0.39 ng/mL, respectively). Nonsignificant differences between serum and seminal gonadal hormones were elicited between Gr2 and controls. Seminal sFas in various varicocele grades demonstrated nonsignificant differences. There were significant positive correlations between seminal sFas with serum FSH, serum LH, semen FSH, sperm abnormal forms percentage, and significant negative correlations with sperm concentration and sperm motility.Conclusion(s)sFas could play a role in germ cell apoptosis in varicocele-associated cases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 91, Issue 2, February 2009, Pages 420–424
نویسندگان
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