کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3939577 1253562 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Concentrations of stromal cell-derived factor-1 and vascular endothelial growth factor in relation to the diameter of human follicles
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Concentrations of stromal cell-derived factor-1 and vascular endothelial growth factor in relation to the diameter of human follicles
چکیده انگلیسی

ObjectiveTo determine the concentrations of stromal cell-derived factor-1 (SDF-1/CXCL12) and vascular endothelial growth factor (VEGF) in individual human preovulatory follicles in relation to their diameter or volume for clarifying the role of these molecules in folliculogenesis.DesignProspective study.SettingResearch laboratory at Kansai Medical University.Patient(s)Twenty-seven women undergoing IVF.Intervention(s)Follicular fluid (FF) was collected from individual follicles. A total of 373 follicles were analyzed.Main Outcome Measure(s)The concentrations of SDF-1 and VEGF in FF and oocyte recovery rates.Result(s)The concentrations of SDF-1 and VEGF in follicles with a diameter ≤14 mm were significantly lower than those in follicles with a diameter ≥15 mm. The concentrations of SDF-1 and VEGF in FF increased with follicular diameters or volume, with concentrations peaking in follicles with a diameter of 18–20 mm or a volume of 3.6–5.0 mL. Furthermore, we found that there exists a positive correlation between the concentrations of SDF-1 and VEGF in FF from follicles ≤20 mm in diameter. The oocyte recovery rates increased with concentrations of SDF-1 and VEGF in FF.Conclusion(s)Our data suggest that SDF-1, as well as VEGF, may play an important role in follicular growth and development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 95, Issue 2, February 2011, Pages 742–746
نویسندگان
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