کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3940369 1253585 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of cytochrome P450 1B1 polymorphism with first-trimester miscarriage
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Association of cytochrome P450 1B1 polymorphism with first-trimester miscarriage
چکیده انگلیسی

ObjectiveTo determine whether the cytochrome P450 1B1 (CYP1B1) Val432Leu polymorphism is associated with risk of miscarriage. We also analyzed the possible interaction between this polymorphism and caffeine intake.DesignThe population-based case-control study included 507 women with miscarriage in the first trimester of pregnancy and 908 controls with a normal first-trimester pregnancy. The controls were frequency matched to cases. The material was analyzed taking maternal age, smoking habits, alcohol intake, caffeine intake, fetal karyotype, nausea, and vomiting into consideration.SettingUniversity hospital and primary care facility.Main Outcome Measure(s)CYP1B1 Val432Leu genotype frequencies in cases and controls.Result(s)Carriers of the CYP1B1 432 Val/Val genotype were at a higher risk of miscarriage in the first trimester of pregnancy (odds ratio = 1.46; 95% confidence interval, 1.02–2.08). We also found a significant interaction between genotype and caffeine intake.Conclusion(s)CYP1B1 Val432Leu polymorphism is associated with first-trimester miscarriage, and it may also modify the risk among coffee drinkers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 86, Issue 5, November 2006, Pages 1498–1503
نویسندگان
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