Cytogenetic analysis of human oocytes remaining unfertilized after intracytoplasmic sperm injection

Oocytes remaining unfertilized after intracytoplasmic sperm injection showed 12.0% aneuploidy (nondisjunction + unbalanced predivision), 3.4% structural aberrations, and 8.5% balanced predivision in fully karyotyped cells. However, the frequently observed complete or partial separation of chromatids, most probably caused by abortive activation, might complicate the evaluation of meiosis I–derived aneuploidy and questions the relevance of balanced predivision.