کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3941301 | 1253607 | 2009 | 7 صفحه PDF | دانلود رایگان |

ObjectiveTo compare the efficacy of highly purified human urinary follicle stimulating hormone (HP-hFSH) versus human recombinant follitropin-alpha (rFSH) in volunteers undergoing controlled ovarian stimulation for IVF.DesignA randomized, controlled, investigator-blind trial.SettingFour assisted reproductive technology centers.Patient(s)One hundred fifty-two IVF patients.Intervention(s)Volunteers, aged 18–39, were randomized to HP-hFSH (n = 76) versus rFSH (n = 76) at a starting dose of 300 IU in down-regulated cycles.Main Outcome Measure(s)Number of oocytes, clinical pregnancy rate, and live birth rate with HP-hFSH versus rFSH.Result(s)The total IU of gonadotropin used did not differ between the two groups. There was no difference in number of oocytes retrieved with HP-hFSH (mean = 16.3) compared with rFSH (mean = 17.1), confidence interval (CI) of difference = −3.79 to +2.18. Clinical pregnancy rate, as defined by the presence of a gestational sac, was 48.7% (CI = 37.0%–60.4%) with HP-hFSH versus 44.7% (CI = 33.3%–56.6%) with rFSH (CI of difference = −11.9% to +19.8%). Live birth rate was 38.2% (29 of 76) in both groups (CI = 27.2%–50.0%), for a difference between groups of 0.0% (CI of the difference = −15.4% to +15.4%).Conclusion(s)There were no statistically significant differences in mean oocyte number, clinical pregnancy rate, or live birth rate between HP-hFSH versus rFSH.
Journal: Fertility and Sterility - Volume 91, Issue 4, April 2009, Pages 1005–1011