کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3941596 1253617 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human leukocyte antigen-G is expressed by the eutopic and ectopic endometrium of adenomyosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Human leukocyte antigen-G is expressed by the eutopic and ectopic endometrium of adenomyosis
چکیده انگلیسی

ObjectiveTo compare the expression of human leukocyte antigen-G (HLA-G) in endometrial samples from patients with and without adenomyosis.DesignLaboratory study using human tissue.SettingUniversity hospital.Patient(s)Thirty-four patients with adenomyosis and 11 with myoma of the uterus.Intervention(s)Human leukocyte antigen-G protein expression and localization with immunohistochemistry.Main Outcome Measure(s)Quantitative analysis of HLA-G protein expression, according to H-score.Result(s)A statistically significant difference was noted in HLA-G expression between the glandular cells of eutopic and ectopic endometrium (Mann-Whitney test, 412). The H-score of the negative control was 0.05 ± 0.03 (mean ± SD). In stromal cells, we observed a statistically significantly higher expression of HLA-G in eutopic endometrium than in ectopic endometrium (Mann-Whitney test, 169), whereas the H-score of the negative control was 0.05 ± 0.02. A statistically significant correlation was found between HLA-G expression in ectopic and eutopic endometrium in patients with adenomyosis, both in glands (r = 0.89) and in stroma (r = 0.78).Conclusion(s)Patients with adenomyosis had HLA-G expression in eutopic and ectopic endometrial cells. This could be an explanation for the cells' ability to escape from the hosts' immunosurveillance and to survive without being eliminated by the immune system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 90, Issue 5, November 2008, Pages 1599–1604
نویسندگان
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