کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3942855 1254048 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of tubal ligation on routes of dissemination and overall survival in uterine serous carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Impact of tubal ligation on routes of dissemination and overall survival in uterine serous carcinoma
چکیده انگلیسی

ObjectiveAbdominal peritoneal implants are characteristic of uterine serous carcinoma (USC). The presumed mechanism of dissemination is retrograde transit via the fallopian tube. We assessed the impact of tubal ligation (TL) on the metastatic profile and survival of USC patients.MethodsPatient risk factors, process-of-care variables, and disease-specific parameters were annotated. Categorical variables were compared using the χ2 test. Overall survival (OS) was estimated via the Kaplan–Meier method.ResultsAmong 211 USC patients, fallopian tube status was documented in 142 patients; 35 had a history of TL and 107 did not. When comparing patients with and without TL, positive peritoneal cytology was present, respectively, in 18.8% vs 45.0% (P = .01) and stage IV disease in 14.3% vs 34.6% (P = .02). Using Cox models, age was the sole significant determinant of OS in stage I/II USC. By contrast, age, lymphovascular space involvement, positive cytology, and TL independently and adversely affected survival in stage III/IV USC. Adjusting for these factors in a multivariable model, the association between TL and OS among patients with advanced disease yielded a hazard ratio of 8.61 (95% CI, 3.08–24.03; P < .001). The prevalence of lymphatic metastasis and nodal tumor burden was significantly greater in patients who underwent ligation.ConclusionPatients with TL had significantly lower rates of positive cytology and stage IV disease than patients without TL. The lymphatic system appeared to be the dominant mode of spread after TL and was associated with a paradoxic worsening of OS, perhaps reflecting a delay in diagnosis.


► Tubal ligation alters the route of carcinomatous dissemination in serous cancers.
► Tubal ligation adversely affects survival of patients with advanced serous cancers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 128, Issue 1, January 2013, Pages 71–76
نویسندگان
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