کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3943573 1254122 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The risk of endometrial cancer in women with BRCA1 and BRCA2 mutations. A prospective study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
The risk of endometrial cancer in women with BRCA1 and BRCA2 mutations. A prospective study
چکیده انگلیسی

ObjectiveTo evaluate the risk of endometrial cancer in women who carry a deleterious mutation in the BRCA1 or BRCA2 genes.Patients and methodsWomen known to carry a BRCA1 or BRCA2 mutation, aged 45 to 70, were identified from an international registry and were followed prospectively. A total of 857 women completed a baseline questionnaire and one or more follow-up questionnaires. Study subjects were followed until diagnosis of endometrial cancer, ovarian cancer, death or the date of completion of the last questionnaire. The expected number of endometrial cancers was calculated using age and country-specific incidence rates.ResultsAfter an average follow-up period of 3.3 years, six women were diagnosed with endometrial cancer, compared to 1.13 cancers expected (SIR = 5.3, p = 0.0011). Four of these six patients used tamoxifen in the past. The risk among women who were never exposed to tamoxifen treatment was not significantly elevated (SIR = 2.7, p = 0.17), but among the 226 participants who had used tamoxifen (220 as treatment and six for the primary prevention of breast cancer) the relative risk for endometrial cancer was 11.6 (p = 0.0004).ConclusionThe main contributor to the increased risk of endometrial cancer among BRCA carriers is tamoxifen treatment for a previous breast cancer. The risk and benefits of prophylactic hysterectomy should be discussed with women with a BRCA mutation considering tamoxifen therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 104, Issue 1, January 2007, Pages 7–10
نویسندگان
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