کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3943926 | 1254140 | 2012 | 5 صفحه PDF | دانلود رایگان |
ObjectiveWe assessed the IHC expression of ER and PR and their prognostic significance in uterine leiomyosarcoma (LMS).MethodsWe identified 43 “high-grade” uterine LMS cases from 7/82–7/07 for whom ER/PR IHC analysis was performed at initial diagnosis at our institution.ResultsDisease was confined to the uterine body in 20/43 (47%). Eighteen (42%) of 43 were ER(+); 17/42 (41%) were PR(+). At last follow-up, 33 (77%) had recurred or progressed, and 23 (54%) had died. PR expression was associated with improved progression-free survival (PFS; P = 0.002) and overall survival (OS; P = 0.03) overall; ER expression was not. After adjusting for stage, ER expression was associated with PFS (P = 0.01), not OS (P = 0.3), and PR expression maintained a significant association with PFS (P = 0.002) and approached a significant association with OS (P = 0.05). Neither ER nor PR expression was associated with outcome in cases with disease outside the uterine body. In cases with confined disease, median PFS for ER(+) or PR(+) cases was not reached compared to 16.9 months for ER(−) cases (95% CI: 8.1–25.7; P = 0.03) and 13.5 months for PR(−) cases (95% CI: 5.9–21.1; P = 0.001). Only 1/10 PR(+) cases recurred and died; 9/10 PR(−) cases recurred, and 5 died. Two of 9 ER(+) cases recurred and died; 8/11 ER(−) cases recurred, and 4 died.ConclusionER/PR expression is associated with survival outcomes in patients with high-grade uterine LMS confined to the uterine body. PR expression seems capable of identifying cases confined to the uterine body, which have better outcomes.
► ER and PR expression may have prognostic value in patients with uterine leiomyosarcoma confined to the uterine body.
► This is not the case for patients with disease outside the uterine body.
Journal: Gynecologic Oncology - Volume 124, Issue 3, March 2012, Pages 558–562