کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3944631 1254219 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of statin on risk of gynecologic cancers: A meta-analysis of observational studies and randomized controlled trials
ترجمه فارسی عنوان
اثر استاتین بر خطر ابتلا به سرطان زنان: یک متاآنالیز مطالعات مشاهده شده و آزمایشات تصادفی کنترل شده
کلمات کلیدی
سرطان دهانه رحم، سرطان آندومتری، سرطان های زنان و زایمان، سرطان تخمدان، استاتین
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی


• We aimed to evaluate the effect of statin on risk of gynecologic cancers.
• Statin use was inverse associated with ovarian cancer risk.
• The protective effect of statin use on endometrial and cervix cancer is suggestive.

Objective. Epidemiologic and clinical findings are inconsistent concerning the risk for gynecologic cancers associated with statin use. We conducted a detailed meta-analysis of all relevant original studies to evaluate the effects of statin on the risk of gynecologic cancers.Methods. We searched PubMed, Embase, and Cochrane library databases up to February 2014 looking for eligible studies. Summary relative risk (RR) estimates and 95% confidence intervals (CIs) were used to calculate the risk using random-effects models.Results. A total of 14 (4 randomized controlled trials, 5 cohorts, and 5 case–control) studies, involving 12,904 gynecologic cancer cases, contributed to the analysis. Pooled results indicated a non-significant decrease of total gynecologic cancer risk among statin users (RR = 0.89; 95% CI, 0.78–1.01). Stratified analyses across cancer site revealed a modest protective effect of statin on ovarian cancer (RR = 0.79; 95% CI, 0.64–0.98), while no association was found for endometrial cancer (RR = 0.90; 95% CI, 0.75–1.07). The effect of statin use against cervical cancer and vulvar cancer is not conclusive. Furthermore, long-term statin use (> 5 years use) did not significantly affect the risk of endometrial cancer (RR = 0.69; 95% CI, 0.44–1.10), but had an obvious decrease on the risk of ovarian cancer (RR = 0.48; 95% CI, 0.28–0.80).Conclusions. Our results suggest that statin use was inversely associated with ovarian cancer risk, and the association was stronger for long-term statin use (> 5 years). The evidence for a protective effect of statin use against other gynecologic cancers is suggestive but not conclusive, which deserves further investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 133, Issue 3, June 2014, Pages 647–655
نویسندگان
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