کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3944647 | 1254220 | 2008 | 5 صفحه PDF | دانلود رایگان |

ObjectivesMatrix metalloproteinase (MMP-7) is a secreted matrilysin, which contributes to tumor progression through breakdown of basement membranes and angiogenesis. Therefore, we aimed to investigate the association of MMP-7 − 181A > G gene polymorphism with risk of cervical cancer.MethodsIn the present case control study, we enrolled a total of 150 cervical cancer patients confirmed by histopathology and 162 unrelated healthy individuals. Polymorphism for MMP-7 gene (− 181A > G) was genotyped by polymerase chain reaction and restriction enzyme length polymorphism.ResultsFrequency of MMP-7 − 181GG genotype and − 181G allele differed significantly between patients with cervical cancer (29.3%) and healthy individuals (19.4%) (P = 0.041; ORGG = 1.94 and P = 0.048; ORG = 1.94). Individuals with MMP-7 − 181GG genotype were at higher risk of stage II of cervical cancer with borderline significance (P = 0.05, OR = 2.78; 95%CI: 0.89–8.69). However, interaction of MMP-7 − 181AG and GG genotypes with tobacco usage did not modulate the cervical cancer risk significantly (OR 2.21, 95%CI = 0.59–8.1 and OR 3.17, 95%CI = 0.64–15.7).ConclusionIndividuals with MMP-7 − 181GG genotype were at significantly higher risk of cervical cancer.
Journal: Gynecologic Oncology - Volume 110, Issue 1, July 2008, Pages 71–75