The MnSOD Val9Ala polymorphism, dietary antioxidant intake, risk and survival in ovarian cancer (Australia)

Objective.We assessed the MnSOD Val9Ala polymorphism and its interaction with dietary antioxidant intake in ovarian cancer risk and survival.Methods.The MnSOD polymorphism was assessed in 543 ovarian cancer cases and 1130 controls. We used regression analysis to model the association between genotype and risk, case-only analyses to estimate risk modification by dietary variables, and proportional hazard models for survival analysis.Results.We found no association between this polymorphism and ovarian cancer risk or survival, nor was there evidence of any interaction with dietary antioxidant intake.Conclusion.The Val9Ala MnSOD polymorphism does not influence ovarian cancer risk or survival.