کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3945605 1254277 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MDM2 SNP 309 human papillomavirus infection in cervical carcinogenesis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
MDM2 SNP 309 human papillomavirus infection in cervical carcinogenesis
چکیده انگلیسی

ObjectiveTo investigate the biological significance of single nucleotide polymorphism (SNP) at murine double-minute 2 homolog (MDM2) promoter 309 in cervical carcinogenesis.MethodsSNP at MDM2 promoter 309 (T/G) together with human papillomavirus (HPV) types was examined in a total of 195 cervical smear samples and 8 human cervical squamous carcinoma cell lines using two independent PCR assays and PCR-RFLP techniques.ResultsForty-one patients with high-grade squamous intraepithelial lesion (HSIL) had higher frequency of high-risk HPV than 102 with low-grade SIL (LSIL) and 52 controls. There was an increased OR (8.88; CI = 2.34–33.63; P = 0.003) for TG + GG genotype in HSIL cases compared to controls among 68 patients with high-risk HPV. Twenty-one cases with HPV types 16 and/or 18 had significantly higher frequency of the TG + GG genotype and G allele than 47 with other types of high-risk HPV. Seven of 8 cervical carcinoma cell lines also showed TG or GG genotype.ConclusionMDM2-SNP309 (T/G) and high-risk HPV infection may be closely associated with cervical carcinogenesis in a Japanese population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 118, Issue 3, September 2010, Pages 258–261
نویسندگان
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