کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3945951 1254308 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum paraoxonase and arylesterase activities in patients with epithelial ovarian cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Serum paraoxonase and arylesterase activities in patients with epithelial ovarian cancer
چکیده انگلیسی

ObjectiveThe HDL-associated paraoxonase and arylesterase activities play a role in decreasing oxidative stress, which is known to contribute to cancer development. The aim of this study was to evaluate serum paraoxonase and arylesterase activities and lipid hydroperoxide (LOOH) levels in patients with newly-diagnosed epithelial ovarian cancer.MaterialsSerum paraoxonase and arylesterase activities, total free sulfhydryl (− SH) levels and LOOH levels were measured in patients with epithelial ovarian cancer (n = 24) and controls (n = 29).ResultsSerum paraoxonase activity and arylesterase activity, as well as − SH levels were significantly lower (p = 0.003, p < 0.001 and p < 0.001, respectively) in patients with epithelial ovarian cancer compared to controls, while LOOH levels were significantly higher (p < 0.001). A significant inverse correlation was found between the stage, grade and CA-125 level of ovarian cancer and paraoxonase activity (rho = − 0.630, p = 0.001 and rho = − 0.601, p = 0.002 and rho = − 0.436, p = 0.033, respectively), arylesterase activity (rho = − 0.601, p = 0.002 and rho = − 0.713, p < 0.001 and rho = −0.580, p = 0.003, respectively), and − SH levels (rho = − 0.642, p = 0.001 and rho = − 0.637, p = 0.001 and rho = − 0.530, p = 0.008, respectively). In contrast, there was a positive correlation between LOOH and the stage, grade and CA-125 level of ovarian cancer (rho = 0.565, p = 0.004 and rho = 0.479, p = 0.018 and rho = 0.642, p = 0.001).ConclusionOur results suggest that diminished paraoxonase and arylesterase activity, − SH levels and increased LOOH levels are associated with particular stage, grade and CA-125 level of ovarian cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 112, Issue 3, March 2009, Pages 481–485
نویسندگان
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