کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3950207 | 1600412 | 2008 | 6 صفحه PDF | دانلود رایگان |
Objective:To evaluate the effect of soy isoflavones on menopausal symptoms in women who do and who do not produce equol, a daidzein metabolite.Method:A randomized, double-blind, placebo-controlled clinical trial was conducted over 6 months with 96 healthy menopausal women. After taking take 135 mg of isoflavones daily for 1 week, the women in the study group were assigned to the equol-producing (EP) or the non-EP group according to the presence or absence of equol in their urine. Menopausal symptoms were evaluated using a modified Kupperman Index.Result:Compared with the placebo group, the scores for hot flashes and excessive sweating were significantly reduced after 3 months, and the scores for weakness, palpitations, limb paresthesia, and total symptoms after 6 months, in the EP group only.Conclusions:Isoflavone supplementation improves menopausal symptoms only in women with the ability to produce equol.
Journal: International Journal of Gynecology & Obstetrics - Volume 102, Issue 1, July 2008, Pages 44–49