کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3953197 | 1600438 | 2006 | 5 صفحه PDF | دانلود رایگان |

Objective: To compare sublingual with vaginal misoprostol for the induction of labor. Methods: This double-blind clinical trial randomized 150 women to receive every 6 h 25 μg of sublingual misoprostol and vaginal placebo or 25 μg of vaginal misoprostol and sublingual placebo. Maternal and neonatal outcomes were analyzed and risk ratios (RRs) with 95% confidence intervals (CIs) calculated. The significance level was 5%. Results: Vaginal delivery rates were 57% in the sublingual group and 69% in the vaginal group (RR, 0.8; 95% CI, 0.6–1.1). There were 11 cases of fetal distress in the sublingual group and 4 cases in the vaginal group (RR, 2.7; 95% CI, 0.9–8.2). There were no significant differences in the number of doses needed, interval between first dose and delivery, incidence of contractility disturbances, or neonatal results. Conclusion: The administration of misoprostol 25 μg by the sublingual route was neither more effective nor safer than the same dose administered vaginally.
Journal: International Journal of Gynecology & Obstetrics - Volume 94, Issue 2, August 2006, Pages 91–95