کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3953738 | 1600392 | 2009 | 4 صفحه PDF | دانلود رایگان |

ObjectiveTo compare hormone levels and clinical outcomes in patients with polycystic ovary syndrome (PCOS) after metformin therapy or laparoscopic ovarian diathermy (LOD) at 6 months follow-up.MethodsA randomized trial was conducted in 126 patients with PCOS who had a history of infertility for at least 1 year and resistance to clomiphene citrate (CC). Patients (n = 63) received metformin treatment or underwent LOD (n = 63).ResultsLevels of follicle-stimulating hormone did not change in either group after the intervention (P > 0.05). Serum levels of testosterone (P < 0.001) and luteinizing hormone (P < 0.001) were significantly lower after the treatment in both groups. The proportion of women with regular menstrual cycles increased significantly to 35% (P < 0.001) in the LOD group and to 49% (P < 0.001) in metformin group compared with before the intervention. Although proportion was higher in the metformin group compared with the LOD group, the difference was not significant (odds ratio 1.81; 95% CI, 0.88–3.69, P = 0.1). Hirsutism decreased significantly from 100% to 79.37% (P < 0.001) in both groups.ConclusionCC-resistant patients with PCOS were treated effectively by both metformin and LOD.
Journal: International Journal of Gynecology & Obstetrics - Volume 107, Issue 3, December 2009, Pages 236–239