کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3956976 | 1255348 | 2009 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Hyperinnervation in Intestinal Deep Infiltrating Endometriosis Hyperinnervation in Intestinal Deep Infiltrating Endometriosis](/preview/png/3956976.png)
Study ObjectiveTo investigate the extent and types of innervation of endometriotic lesions in various regions of the bowel.DesignRetrospective nonrandomized immunohistochemical study (Canadian Task Force classification II-3.SettingUniversity-based laboratory.PatientsThirty-six women undergoing laparoscopy or laparotomy because of deep infiltrating endometriosis in various regions of the bowel, including the sigmoid colon, appendix, and rectum.InterventionsImmunohistochemical staining of endometriotic specimens with antibodies against protein gene product 9.5, neurofilament, nerve growth factor, nerve growth factor receptors tyrosine kinase receptor A and p75, growth-associated protein 43, substance P, neuropeptide Y, and vasoactive intestinal peptide to demonstrate myelinated, unmyelinated, sensory, and autonomic nerve fibers.Measurements and Main ResultsThere were significantly more nerve fibers in intestinal deep infiltrating endometriosis (mean [SD] 172.6 [94.2]/mm2) than in other deep infiltrating endometriotic lesions (e.g., cul-de-sac and uterosacral ligament) (67.6 [65.1]/mm2; p < .01). Intestinal deep infiltrating endometriosis was innervated abundantly by sensory Aδ,sensory C, cholinergic, and adrenergic nerve fibers. Nerve growth factor, tyrosine kinase receptor A, and p75 were strongly expressed in endometriotic lesions, and growth-associated protein-43 was also strongly expressed in the endometriosis-associated nerve fibers.ConclusionThe hyperinnervation in intestinal deep infiltrating endometriosis may help to explain why patients with this type of lesion have more severe pain.
Journal: Journal of Minimally Invasive Gynecology - Volume 16, Issue 6, November–December 2009, Pages 713–719