کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3961741 | 1255619 | 2009 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Fetal–maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells Fetal–maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells](/preview/png/3961741.png)
Human leukocyte antigen-C (HLA-C) is the only polymorphic classical histocompatibility antigen expressed by fetal trophoblasts at the fetal–maternal interface. Interactions between HLA-C and decidual natural killer (NK) cells may facilitate trophoblast invasion into maternal tissue. Thus far no evidence has been provided that decidual T cells specifically recognize and respond to fetal alloantigens at the fetal–maternal interface. In this study, we show that pregnancies containing a HLA-C mismatched child induce an increased percentage of CD4+CD25dim activated T cells in decidual tissue. In addition, HLA-C mismatched pregnancies exhibit a decidual lymphocyte response to fetal cells and contain functional CD4+CD25bright regulatory T cells in decidual tissue, whereas HLA-C matched pregnancies do not. This suggests that decidual T cells specifically recognize fetal HLA-C at the fetal–maternal interface but are prevented from inducing a destructive immune response in uncomplicated pregnancies.
Journal: Journal of Reproductive Immunology - Volume 82, Issue 2, November 2009, Pages 148–157