کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3962190 | 1255644 | 2006 | 6 صفحه PDF | دانلود رایگان |

IFN-τ is a signaling protein secreted by the bovine conceptus during the peri-implantation period and responsible for pregnancy recognition. Its main role is the prevention of pulsatile release of luteolytic PGF2α, but it also exerts immunomodulatory activities characteristic for other type I interferons. The aim of the study was to examine the effect of IFN-τ on the proliferation and distribution of peripheral blood lymphocyte subsets during one-way mixed lymphocyte reaction (MLR) in cows and heifers. IFN-τ inhibited the proliferative response of lymphocytes in MLR both in cows and heifers in a dose-dependent manner, but cow lymphocytes were less susceptible than those ones from heifers. It was also showed that IFN-τ differentially changed lymphocyte subsets distribution in MLR in cows and heifers. In cows, the relative percentage of CD8+ cells after MRL in the presence of IFN-τ was significantly lower than in heifers. Differential effect of rIFN-τ on proliferation and lymphocyte subsets distribution in a one-way MRL in cows and heifers indicated that the age of the mother is an important factor in immunomodulatory effect towards developing bovine embryo.
Journal: Journal of Reproductive Immunology - Volume 71, Issue 2, October 2006, Pages 126–131