کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3963997 1255775 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa
چکیده انگلیسی

Chlamydia trachomatis is a significant human pathogen with potentially severe disease sequelae in the genital tract, including infertility. A successful vaccine will need to effectively target immunity to the genital mucosa. Intranasal immunisation with cholera toxin (CT) can target immunity to the genital tract, but has the potential to cause neurological side effects. CTA1-DD is a non-toxic potent mucosal adjuvant which combines the enzymatic properties of CT, with a B cell targeting moiety. Here, we demonstrate that intranasal immunisation with CTA1-DD and chlamydial Major Outer Membrane Protein (MOMP) results in the induction of neutralising systemic and mucosal antibodies, and reduces the level of chlamydial shedding following intravaginal challenge with Chlamydia muridarum. Thus, CTA1-DD is an effective adjuvant for vaccine development against Chlamydia trachomatis, and possibly also a range of other genital pathogens.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproductive Immunology - Volume 81, Issue 1, July 2009, Pages 34–38
نویسندگان
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