کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3964267 1600707 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
FAS and FAS ligand gene polymorphisms in Egyptian females with preeclampsia
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
FAS and FAS ligand gene polymorphisms in Egyptian females with preeclampsia
چکیده انگلیسی

We aimed to evaluate the association of Fas polymorphism and the Fas ligand with preeclampsia, investigating whether the G 670 Fas gene variant and the Fas Ligand INV2nt 124 G variant had a differential distribution in patients with preeclampsia. The preeclamptic group consisted of 50 pregnant women who developed preeclampsia, while the control group consisted of 50 age-matched pregnant women with uncomplicated pregnancies. Fas and Fas ligand gene polymorphisms were tested using polymerase chain reaction–restriction fragment length polymorphism. Regarding the Fas 670 A > G polymorphism, statistically significant differences were found between the two groups regarding the AA and GG/AG genotypes as well as the A, G allele frequency, while no statistically significant differences were found regarding AG or GG genotypes. Regarding the FasLG IVS2nt 124 A > G polymorphism, no statistically significant differences were found between the two groups studied. Concerning the Fas 670 A > G gene, no statistically significant differences between the severe and mild preeclampsia groups regarding the A allele frequency were found. Concerning the FasLG IVS2nt 124 A > G gene, there were no statistically significant differences between the severe and mild preeclampsia groups regarding the A allele frequency or the G allele frequency. The presence of the Fas gene polymorphism Fas A670G is associated with an increased risk of preeclampsia, while the presence of FasLG IVS2nt 124 A > G gene may be protective against preeclampsia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproductive Immunology - Volumes 104–105, October 2014, Pages 63–67
نویسندگان
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