کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3964393 | 1600714 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reduced IFN-γ and IL-10 responses to paternal antigens during and after pregnancy in allergic women
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کلمات کلیدی
PBMCMLRMLCT helperTh1/Th2 - Th1 / Th2Allergy - آلِرژیimmunoglobulin - ایمونوگلوبولینPregnancy - بارداریperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیTreg cells - سلولهای TregRegulatory T cells - سلولهای تی تنظیمکنندهMixed leukocyte culture - فرهنگ مخلوط لکوسیتmixed leukocyte reaction - واکنش مخلوط لکوسیتPost partum - پست بخش
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Normal pregnancy and allergy are both characterized by a T helper (Th) 2 deviation. In the current study, we hypothesized that paternal antigen-induced cytokine responses during pregnancy would be deviated toward Th2 and an anti-inflammatory profile, and that the Th2 deviation would be more pronounced in allergic pregnant women. Blood samples were collected longitudinally on three occasions during pregnancy and two occasions post partum (pp). Of the 86 women initially included, 54 women had a normal pregnancy and completed the sampling procedures. Twelve women fulfilled the criteria for allergy (allergic symptoms and circulating immunoglobulin [Ig] E antibodies to inhalant allergens) and 20 were non-allergic (nonsensitized without symptoms). The levels of Th1- and Th2-associated cytokines and chemokines, the Th17 cytokine IL-17 and the anti-inflammatory cytokine IL-10 of the groups were compared. Paternal antigen-induced IL-4 and IL-10 responses increased between the first and the third trimester. Allergy was associated with decreased paternal antigen-induced IFN-γ and CXCL10 secretion in the nonpregnant state (one year pp) and also decreased IFN-γ/IL-4 and IFN-γ/IL-13 ratios during pregnancy. We also observed a decreased paternal antigen-induced IL-10 response in allergic compared with non-allergic women during pregnancy, along with a decreased IL-10/IL-13 ratio. In conclusion, our findings support the hypothesis of lower Th1 responses toward paternal antigens in allergic than in non-allergic women, but also indicate that allergy is associated with a lower capacity to induce anti-inflammatory IL-10 responses after paternal antigen stimulation during pregnancy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproductive Immunology - Volume 95, Issues 1â2, September 2012, Pages 50-58
Journal: Journal of Reproductive Immunology - Volume 95, Issues 1â2, September 2012, Pages 50-58
نویسندگان
Marie Persson, Christina Ekerfelt, Jan Ernerudh, Leif Matthiesen, Martina Sandberg Abelius, Yvonne Jonsson, Göran Berg, Maria C. Jenmalm,