کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3964994 1600723 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association study of IL-10 and IFN-γ gene polymorphisms in Iranian women with preeclampsia
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Association study of IL-10 and IFN-γ gene polymorphisms in Iranian women with preeclampsia
چکیده انگلیسی

Preeclampsia (PE) is one of the most serious disorders of human pregnancy and Th1/Th2 imbalance may play a role in its etiology. Considering that cytokine production is under genetic control, in this study we have investigated IFN-γ + 874 (T/A) and three bi-allelic IL-10 promoter polymorphisms in a total of 134 preeclamptic women compared to 164 healthy women. It was shown that the IL-10 −1082 G allele frequency increases significantly in patients compared to the control group (P = 0.045). No significant differences were found in any other genotype or allele frequencies of IL-10 and IFN-γ genes between the two groups. In addition, the frequencies of three common IL-10 haplotypes (GCC, ACC, ATA) did not show any significant difference between the study groups. Since the presence of G nucleotide at position −1082 of IL-10 gene is associated with reduced cytokine production, therefore, the higher frequency of IL-10 −1082 G allele in preeclamptic patients compared to controls may be considered as a genetic susceptibility factor for the development of PE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproductive Immunology - Volume 72, Issues 1–2, December 2006, Pages 118–126
نویسندگان
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