کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3965102 1255881 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IL-13 induces the expression of the alternative activation marker Ym1 in a subset of testicular macrophages
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
IL-13 induces the expression of the alternative activation marker Ym1 in a subset of testicular macrophages
چکیده انگلیسی

Macrophages are thought to play an important role in the maintenance of immune privilege in the testis, which functions to prevent immune responses to developing sperm. Two populations of macrophages are known to exist in the testis, one of which exhibits immunosuppressive activity. Macrophages that are alternatively activated with either IL-4 or IL-13 have been shown to be anti-inflammatory and promote wound healing. Expression of the Ym1 protein is an established marker of alternatively activated macrophages. Testicular macrophages were examined for expression of Ym1 protein, and it was found to be highly expressed in a subpopulation of CD11b+ cells. Furthermore, we have shown that Ym1 protein expression in the testis is dependent upon IL-13R signaling, and that IL-13 is produced in the testis. These data suggest that IL-13 plays a role in testicular immune privilege by the maintenance of an alternatively activated macrophage population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproductive Immunology - Volume 78, Issue 2, July 2008, Pages 140–148
نویسندگان
, , , , , ,