کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3965104 1255881 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The HLA-G 14bp gene polymorphism and decidual HLA-G 14bp gene expression in pre-eclamptic and normal pregnancies
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The HLA-G 14bp gene polymorphism and decidual HLA-G 14bp gene expression in pre-eclamptic and normal pregnancies
چکیده انگلیسی

Trophoblast expression of the non-classical MHC, HLA-G, is considered essential for feto-maternal immune tolerance and successful placentation in pregnancy. The HLA-G 14 bp polymorphism in the 3′-untranslated region (UTR) of the HLA-G gene has been reported to be associated with development of pre-eclampsia (PE). In this study, maternal (peripheral blood, n = 54) and fetal (cord blood, n = 57) HLA-G 14 bp genotypes have been determined by PCR in pre-eclamptic and normal pregnancies. In addition, HLA-G 14 bp gene expression in decidua basalis (n = 59) was analyzed by RT-PCR. The pre-eclamptic syndrome was neither associated with the HLA-G 14 bp genotype (maternal or fetal), nor with altered decidual HLA-G 14 bp gene expression. Furthermore, the HLA-G 14 bp mRNA expressed in decidua basalis was of fetal origin and all potential transcripts, as predicted from the fetal HLA-G 14 bp genotype, were expressed. In contrast to previous findings, we found no correlation between the HLA-G 14 bp polymorphism and fetal growth. In conclusion, the fetal HLA-G 14 bp genotype is reflected in the decidual HLA-G mRNA splice form profile, but does not appear to be associated with increased risk for development of PE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproductive Immunology - Volume 78, Issue 2, July 2008, Pages 158–165
نویسندگان
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