کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3965810 1256018 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An insight into normal and pathological pregnancies using large-scale microarrays: lessons from microarrays
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
An insight into normal and pathological pregnancies using large-scale microarrays: lessons from microarrays
چکیده انگلیسی

In the introduction, we briefly recall old but classic evidence that there is no tolerance to paternal alloantigens in a first pregnancy. Therefore, we performed small- and large-scale microarrays in CBA × DBA/2 and CBA × BALB/c combinations, recently described as a murine model for preeclampsia. Our results are in line with other data suggesting a very early deregulation of local immune vascular events rather than a break of immune tolerance. Other data presented at the Tioman 2010 Preeclampsia Workshop supporting this hypothesis are briefly summarised, as well as indications and caveats from a recent human microarray on implantation failure and recurrent pregnancy loss.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproductive Immunology - Volume 89, Issue 2, May 2011, Pages 163–172
نویسندگان
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