کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3965816 1256018 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stress increases VCAM-1 expression at the fetomaternal interface in an abortion-prone mouse model
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Stress increases VCAM-1 expression at the fetomaternal interface in an abortion-prone mouse model
چکیده انگلیسی

Sound stress exposure increases fetal loss via inflammatory pathways. Inflammation is known to up-regulate cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1), which mediates the adhesion of leukocytes to the vascular endothelium. In this work, we studied the frequency of VCAM-1+ vessels at the fetomaternal interface in stressed and non-stressed pregnant CBA/J female mice mated with DBA/2J (high fetal loss model) or BALB/c (low fetal loss model) males. The high fetal loss model had fewer large vessels on gestation day 6.5, and stress reduced the frequency of large vessels to a similar number in both high and low fetal loss models. In the high fetal loss model, however, the frequency of VCAM-1+ vessels was dramatically increased. This study shows that VCAM-1 expression is modulated by stress at the fetomaternal interface in abortion-prone cross-breeding.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproductive Immunology - Volume 89, Issue 2, May 2011, Pages 207–211
نویسندگان
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