کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3965961 1600720 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunoactivation in preeclampsia: Vδ2+ and regulatory T cells during the inflammatory stage of disease
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Immunoactivation in preeclampsia: Vδ2+ and regulatory T cells during the inflammatory stage of disease
چکیده انگلیسی

Recent data suggest a dominant role of the innate, rather than the adaptive immune system in pregnancy-related immunoregulation. γ/δ T cells, that comprise a minor subpopulation of human peripheral blood lymphocytes, represent a link between the innate and the acquired immune systems. However little is known about how they function in preeclampsia, which is suggested to be associated with a Th1 predominant immune response. The aim of our study was to investigate the presence and phenotype of Vδ2+ cells and of regulatory T cells in the pathogenesis of preeclampsia. Since Vδ2+ T cell function has been shown to be altered in patients with preeclampsia we investigated the expression of perforin, Fas and TIM-3 by Vδ2+ T cells and the possible role of activating and inhibitory NK cell receptors as well as of regulatory T cells. Vδ2+ T cells of preeclamptic patients demonstrated an increased perforin and IFNγ production, which could be explained by dysregulation of NK cell receptor expression. These Th1 polarized cells were less susceptible to apoptosis than Vδ2+ T cells from healthy pregnant women. Our data suggest that activated Vδ2+ T cells of preeclamptic women have an increased cytotoxic potential, which may be due to altered expression of NK cell inhibitory and activating receptors. In this study we report a series of observations, which taken together suggest the role of multiple pathways in generating an exaggerated systemic inflammatory response observed in the clinical stage of preeclampsia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproductive Immunology - Volume 80, Issues 1–2, June 2009, Pages 100–108
نویسندگان
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