کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3966042 | 1600755 | 2016 | 5 صفحه PDF | دانلود رایگان |
Objective: To evaluate the effect of adjuvant sildenafil on ovarian responsiveness in low responders undergoing IVF. Patient(s) and methods: Prospective randomized, double-blind, placebo controlled study was conducted at Obstetrics and Gynecology department, Tanta university hospital and Center of Assisted Reproduction, Om El-kora Hospital, Tanta, Egypt. Sixty patients were classified as low responders undergoing IVF. Supplementation with sildenafil (50 mg daily) or placebo to a gonadotropin releasing hormone antagonist protocol was provided. Result(s): There were no significant differences in total number of 75 IU FSH ampoules used (60.025 ± 5.52) versus (66.025 ± 4.51), the number of mature follicles recruited (3.35 ± 1.137) versus (2.95 ± .826), and the number of oocytes retrieved (3.95 ± 1.395) versus (3.65 ± 1.137) or cycle cancelation rates (26.7% in the treatment group versus 23.3% in placebo group). Conclusion: Adjuvant sildenafil does not enhance ovarian responsiveness in cases of previous low ovarian response to controlled ovarian hyperstimulation.
Journal: Middle East Fertility Society Journal - Volume 21, Issue 3, September 2016, Pages 175–179