The relationship between Anti-müllerian hormone and the clinical, biochemical and sonographic parameters in women with polycystic ovarian syndrome

Background and aim of the studyAnti-müllerian hormone (AMH) is a dimeric glycoprotein, which is secreted exclusively by granulose cells of primary, preantral, and small antral follicles (4–6 mm). Women with polycystic ovary syndrome (PCOS) have a 2- to 3-fold increase in the serum AMH concentration, which corresponds to the 2- to 3-fold increase in the number of small follicles seen in PCOS. The aim of this study was to assess the relationship between AMH and the clinical, biochemical and sonographic parameters in women with PCOS.Study designIn this prospective observational study, serum AMH was measured in 200 PCOS women attending 2 fertility clinics in Minia, Egypt. The relationship between AMH and the clinical, biochemical and sonographic parameters of PCOS was studied.ResultsAMH levels were found to have significant positive correlation with cycle length (r = 0.706, P < 0.01), modified Ferriman Gallwey (FG) score for hirsutism (r = 0.329, P < 0.01), mean ovarian volume (r = 0.498, P < 0.01), antral follicle count (AFC) (r = 0.963, P < 0.01) and total testosterone (r = 0.272, P < 0.01).ConclusionIn conclusion, AMH is strongly correlated with the clinical, biochemical and sonographic features of PCOS.