کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3967020 1256217 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sickle cell disease in pregnancy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Sickle cell disease in pregnancy
چکیده انگلیسی

Sickle cell disease (SCD) is an autosomal recessive condition, which leads to life-long haemolytic anaemia. Clinical features are intermittent episodes of severe pain and chronic complications including a high risk of stroke, renal dysfunction, retinopathy and cardiopulmonary disease. Advances in treatment have enabled affected women to live to childbearing age. Pregnancy and childbirth with SCD are considered high-risk, and are associated with increased maternal and fetal morbidity and mortality. A universal newborn screening programme provides for early identification of all affected newborns. The antenatal screening programme identifies women with haemoglobinopathies and offers them the option of fetal screening. Management of women with SCD begins with preconceptual care, which involves counselling, screening for end organ damage and a review of their medications. Multidisciplinary antenatal care is desirable. Contraception should be discussed post pregnancy. The only proven cure for this condition is correction of the genetic defect by haematopoietic stem cell transplantation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Obstetrics, Gynaecology & Reproductive Medicine - Volume 22, Issue 9, September 2012, Pages 254–263
نویسندگان
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