Low-intensity IVF: real progress?

A recent publication in this journal strongly advocated low-intensity IVF (LI-IVF) after presenting the authors’ experience with minimal ovarian stimulation (mini-IVF). The data presented failed to support their conclusions. Therefore, presented here is a critique of their manuscript and of uncontrolled clinical use of LI-IVF, in general. In the absence of properly controlled studies, all forms of LI-IVF should be considered experimental and be offered only in well-controlled research settings and with appropriate informed consent.