کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3974583 1257002 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Early origins of chronic obstructive pulmonary disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Early origins of chronic obstructive pulmonary disease
چکیده انگلیسی

SummaryChronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide and a significant challenge for adult physicians. However, there is a misconception that COPD is a disease of only adult smokers. There is a growing body of evidence to support the hypothesis that chronic respiratory diseases such as COPD have their origins in early life. In particular, adverse maternal factors will interact with the environment in a susceptible host promoting altered lung growth and development antenatally and in early childhood. Subsequent lung injury and further gene–environment interactions may result in permanent lung injury manifest by airway obstruction predisposing to COPD. This review will discuss the currently available data regarding risk factors in early life and their role in determining the COPD phenotype.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Fetal and Neonatal Medicine - Volume 17, Issue 2, April 2012, Pages 112–118
نویسندگان
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