کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4011544 1261151 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pathophysiology of human glaucomatous optic nerve damage: Insights from rodent models of glaucoma
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی و میکروب شناسی (عمومی)
پیش نمایش صفحه اول مقاله
Pathophysiology of human glaucomatous optic nerve damage: Insights from rodent models of glaucoma
چکیده انگلیسی

Understanding mechanisms of glaucomatous optic nerve damage is essential for developing effective therapies to augment conventional pressure-lowering treatments. This requires that we understand not only the physical forces in play, but the cellular responses that translate these forces into axonal injury. The former are best understood by using primate models, in which a well-developed lamina cribrosa, peripapillary sclera and blood supply are most like that of the human optic nerve head. However, determining cellular responses to elevated intraocular pressure (IOP) and relating their contribution to axonal injury require cell biology techniques, using animals in numbers sufficient to perform reliable statistical analyses and draw meaningful conclusions. Over the years, models of chronically elevated IOP in laboratory rats and mice have proven increasingly useful for these purposes. While lacking a distinct collagenous lamina cribrosa, the rodent optic nerve head (ONH) possesses a cellular arrangement of astrocytes, or glial lamina, that ultrastructurally closely resembles that of the primate. Using these tools, major insights have been gained into ONH and the retinal cellular responses to elevated IOP that, in time, can be applied to the primate model and, ultimately, human glaucoma.


► Despite the lack of a collagenous lamina, elevated IOP produces optic nerve head damage in rodent eyes.
► Rodent models of glaucoma are well suited for understanding cellular mechanisms of pressure-induced optic nerve damage.
► Rodent models allow evaluation of retinal as well as optic nerve head mechanisms of injury.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 93, Issue 2, August 2011, Pages 156–164
نویسندگان
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