TRPV1 receptors are involved in protein nitration and Müller cell reaction in the acutely axotomized rat retina

► Axotomy reduces the number of TRPV1-positive cells and TRPV1 expression in the retina. ► TRPV1 antagonism does not reduce RGC loss after acute optic nerve axotomy. ► TRPV1 activation induces protein nitration and Müller cell reaction in normal retinas. ► TRPV1 blockade after axotomy lowers protein nitration and Müller cell reaction.