Eccentric variation of corneal sensitivity to pneumatic stimulation at different temperatures and with CO2

The purpose was to measure corneal sensitivity at multiple corneal positions using pneumatic stimuli, at room temperature and at ocular surface temperature (with and without CO2 added), in 15 healthy participants. Sensitivity of central, mid-peripheral, and peripheral cornea was measured using a computer-controlled modified Belmonte esthesiometer to deliver pneumatic cool (air at 20 °C), mechanical (air at 50 °C), and chemical stimuli (air at 50 °C with CO2 added). The ascending method of limits and method of constant stimuli were adopted to determine the threshold to these stimuli at each location. Sensitivity across the cornea using pneumatic stimuli at different temperatures and chemical stimuli varied only slightly. These patterns of variation are different to what has been previously reported using Cochet-Bonnet esthesiometry.