کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4012788 | 1261210 | 2006 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Latanoprost therapy reduces the levels of TGF beta 1 and gelatinases in the aqueous humour of patients with exfoliative glaucoma Latanoprost therapy reduces the levels of TGF beta 1 and gelatinases in the aqueous humour of patients with exfoliative glaucoma](/preview/png/4012788.png)
The aim of the present study was to evaluate the effect of latanoprost monotherapy on the aqueous humour concentrations of TGF-β1, MMP-2, TIMP-2, MMP-9 and gelatinolytic activity in patients treated for exfoliative glaucoma (XFG). Aqueous samples from 50 XFG patients treated with latanoprost and 50 age-matched XFG patients treated with timolol were collected during phacoemulsification cataract surgery. The concentrations of TGF-β1, MMP-2, TIMP-2, MMP-9 and gelatinase activity were determined by commercial immunoassays. The mean active TGF-β1 concentration in the aqueous was significantly lower in XFG patients treated with latanoprost compared with those treated with timolol (3.1±0.65 vs 13.4±1.5 pg ml−1); (P=0.0014). The mean total MMP-2 concentration was lower in latanoprost treated patients (31.75±3.8 vs 81.5±7.2 ng ml−1); (P<0.0001). The TIMP-2 concentration was also lower in XFG-latanoprost treated patients (73.8±6.81 vs 101.28±7.29 ng ml−1); (P=0.0096). Latanoprost monotherapy has a marked effect on the aqueous concentration of TGF-β1, MMP-2 and TIMP-2 in XFG patients. A better understanding of its effect on the pathobiology of the disease may lead to its earlier use in the disease process to prevent progression from XFS to XFG.
Journal: Experimental Eye Research - Volume 82, Issue 2, February 2006, Pages 319–322