کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4031985 1602833 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pathogenesis of herpes stromal keratitis – A focus on corneal neovascularization
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
پیش نمایش صفحه اول مقاله
Pathogenesis of herpes stromal keratitis – A focus on corneal neovascularization
چکیده انگلیسی

The cornea is a complex sensory organ that must maintain its transparency for optimal vision. Infections such as with herpes simplex virus can result in blinding immunoinflammatory reactions referred to as herpes stromal keratitis (HSK). In this review we discuss the pathogenesis of HSK referring to work mainly done using animal model systems. We briefly discuss the role of multiple cell types and soluble mediators but focus on the critical role of corneal vascularization (CV) in contributing to corneal damage. We describe how VEGF and other angiogenic molecules are induced following infection and discuss the many ways by which CV can be controlled. Speculations are made regarding future approaches that could improve the management of HSK.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Retinal and Eye Research - Volume 33, March 2013, Pages 1–9
نویسندگان
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