کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4035068 | 1263504 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Retinal degeneration in children: Dark adapted visual threshold and arteriolar diameter
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
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چکیده انگلیسی
To assess the condition of the retina in children with retinal degeneration due to Bardet-Biedl syndrome (BBS, n = 41), Leber congenital amaurosis (LCA, n = 31), or Usher syndrome (USH, n = 13), the dark adapted visual threshold (DAT) and arteriolar diameters were measured. Compared to controls, the initial DATs of nearly all (83/85) were significantly elevated, and in 26/62 with serial DATs, significant progressive elevation occurred. Arteriolar diameters were significantly attenuated and narrowed with age in BBS and USH, but not LCA. Higher DATs were associated with narrower arterioles. Such non-invasive procedures can document the natural history of these retinal diseases and have the potential to assess response to future treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vision Research - Volume 48, Issue 3, February 2008, Pages 325–331
Journal: Vision Research - Volume 48, Issue 3, February 2008, Pages 325–331
نویسندگان
Ronald M. Hansen, Susan E. Eklund, Ilan Y. Benador, Julie A. Mocko, James D. Akula, Yao Liu, M. Elena Martinez-Perez, Anne B. Fulton,