A versatile solvent-free azide–alkyne click reaction catalyzed by in situ generated copper nanoparticles

A general, high-yielding and efficient methodology for the copper catalyzed azide–alkyne cycloaddition (CuAAC) reaction catalyzed by in situ generated copper nanoparticles (CuNPs) or their clusters is reported. This simple reaction is facile in water, organic solvents and solvent-free conditions under ambient, open-air conditions and requires no special reaction conditions and chromatographic separation.

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► In situ generated copper nanoparticles or their clusters catalyzed azide alkyne click reaction under ambient and open air conditions.
► This reaction is facile in organic medium, aqueous medium and solvent free conditions.
► Rate of the reaction is faster and product can be isolated by simple filtration.
► This methodology is environmentally benign and green.